Gastrointestinal Pharmacology

Gastrointestinal Pharmacology

Unit 8: Gastrointestinal Pharmacology

Gastrointestinal Pharmacology
Gastrointestinal Pharmacology

Welcome to Unit 8 of Advanced Pharmacology
There are a wide variety of drugs used to treat gastrointestinal disorders. Several groups of drugs are used almost exclusively to treat GI conditions. Our focus will be primary care thus intravenous formulations will not be discussed. Clinical use and dosing of drugs will be the focus as with other units and include an emphasis on rational drug selection and patient education.
Primary care providers also see a variety of GI disorders, including gastroesophageal reflux disease and peptic ulcer disease. Over the past several years, over-the-counter medications have become available to treat these conditions. However, it is important to understand the underlying pathophysiology, and know when over-the-counter treatment is ineffective. Stepwise approaches to care and special population considerations will be discussed.
Unit Learning Objectives

Examine the principles of pathophysiology and therapeutics that direct the pharmacotherapeutic interventions affecting the gastrointestinal system (CLO 1)
Analyze the pharmacokinetic and pharmacodynamic actions of agents affecting the gastrointestinal system (CLO 2)
Apply critical-thinking processes to the management and evaluation of expected effects, potential adverse effects, and potential interactions of pharmacological agents affecting the gastrointestinal system (CLO 1,2)
Apply the evidence for pharmacotherapeutic interventions in a patient with gastrointestinal system disorders (CLO 1,2,3)
Evaluate the impact of pharmacogenomics, access, cost, quality, and safety on prescribing for Drugs Affecting the Gastrointestinal System (CLO 4)

Week 10/Unit 8 “To Do” List

Complete High-Yield Med Review Quiz by Sunday Week 10
Unit 6 & 7 Exam available Thursday 11/10 to Saturday 11/12 (Access via Respondus)

Learning Materials
Learning Materials

Lectures & E-Book

Busti, A. J. (2022). NP Curriculum Support-Advanced Pharmacology for NPs. MedEducation, LLC.


5-ASA Derivatives
Fiber, laxatives, Stool Softeners


Drug Food Interactions
Drug Gastric Acid Interactions

Optional Learning Resources:

Parkes, C. (2019a, June 26). Nursing pharmacology – H2 receptor antagonists, PPIs, sucralfate, antacids, prostaglandins [Video]. YouTube.
Parkes, C. (2019b, June 26). Nursing pharmacology – antiemetic, antidiarrhea medications and prokinetic agents [Video]. YouTube.


Khan Academy. (2018a). Advanced gastrointestinal physiology. Retrieved March 11, 2021, from
Khan Academy. (2018c). Gastrointestinal system diseases. Retrieved March 11, 2021, from

HYMR Quiz – GI

Following review of all assigned lectures and correlating E-book chapters in High Yield Med Review, you will complete the module quiz in the HYMR platform.

From the Dashboard select “EXAMS”
Navigate to the “GI-Self Assessment” 
Click “Take Exam”

You will have one attempt to complete 5 questions in 10 minutes. Once completed, please take a screen shot of your score and upload to this assignment tab for grading. This quiz is worth 20 points, so based on your % score you will receive the correlating points below.

20 points

18 points

16 points

14 points

12 points

10 points

8 points

6 points

4 points

2 points

No submission
0 points

*Please note, faculty are able to view your time and activity in HYMR.*

Unit Conclusion
Unit Conclusion

As we wrap up unit 8 of Advanced Pharmacology, we discussed the wide variety of drugs used to treat gastrointestinal disorders. We also learned in-depth treatment of GI disorders. Stepwise approaches to care and special population considerations are always important to remember when prescribing medications. Recall that rational drug selection emphasizes concentrating on resolving or treating the underlying disease state while reducing side effects.


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